Cambridge, MA
Date Posted: March 01, 2016
Employment Type: Contract To Hire
Job Id: 6619

Job Description

Principal Research Associate   

Position Summary

Analytical Development Scientist with a strong background in mass spectrometry (particularly LC/MS) analysis of biomolecules (mRNA, DNA, proteins/peptides, glycans, etc). This position will primarily focus on developing state-of-the-art methods to characterize mRNA (including structure, identity, purity, and impurity analysis) as well as other molecules associated with the production of mRNA therapeutics.



  • Develop state-of-the-art analytical methods to characterize mRNA, DNA, and other biomolecules
  • Provide analytical development support to Process Development, Production, and CMC for platform investigations and regulatory submissions
  • Qualify methods to be for fit for use
  • Transfer robust analytical methods and train appropriate personnel in their use (both internally and externally)

Minimum Qualifications

  • MS with at least 3 years of industry experience, or PhD
  • At least 5 years of demonstrated, hands-on experience with mass spectrometry
  • Ability to work independently or collaboratively, as required
  • Ability to handle multiple projects in a fast paced environment
  • Strong interpersonal skills with an eagerness to work with and support colleagues in other departments

Preferred Qualifications

  • Experience with LC/MS and high-resolution mass spectrometry
  • Experience with oligonucleotide characterization, peptide mapping, glycan mapping, PTM analysis, intact mass analysis, or similar techniques
  • Ability to develop and implement methods for high throughput or (semi-)automated data analysis
  • Familiarity with programming
  • Familiarity with nucleic acid biochemistry


  • Innovative/creative problem solving
  • Willingness to learn new concepts and challenge boundaries
  • Organization and attention to detail
  • Adaptability to change

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